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Ondane mengandung ondansentron, dimana merupakan obat antiemetik yang digunakan untuk meredakan mual dan muntah akibat kemoterapi serta pencegahan mual dan muntah paska operasi. Ondansetron bekerja sebagai antagonis reseptor 5-HT3 yang memblok serotonin pada Chemoreceptor Trigger Zone (CTZ). Pemblokan ini menyebabkan efek antiemetik (anti mual.


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Epidemiological studies have identified a small increased risk of cleft lip and/or cleft palate in babies born to women who used oral ondansetron during the first trimester of pregnancy. Healthcare professionals are advised that if there is a clinical need for ondansetron in pregnancy, patients should be counselled on the potential benefits and.


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Dosis. Dewasa : Untuk pencegahan mual dan muntah pasca operasi : 8 mg 1 jam sebelum anestesi, selanjutnya 8 mg tiap 8 jam sampai dengan 16 jam. Untuk mual dan muntah karena radioterapi : 8 mg per oral tiap 8 jam, 1-2 jam sebelum radioterapi. Anak > 4 tahun : 5 mg/m2 IV selama 15 menit, diberikat setiap 12 jam selama 5 hari.


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ondansetron HCl 4 mg tablet. Information last revised November 2023. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider. The above information is intended to supplement, not substitute for, the.


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Dosis. PENGGUNAAN OBAT INI HARUS SESUAI DENGAN PETUNJUK DOKTER. Pencegahan mual muntah paska operasi Dewasa dan anak >17 tahun: Awal 8 mg per oral 1-2 jam sebelum anestesi, dilanjutkan dengan 8 mg setelah 8-12 jam. Anak 4-11 tahun: 4 mg 30 menit sebelum kemoterapi. Ulangi dosis setelah 4 dan 8 jam dari dosis awal Mual muntah paska operasi: 16.


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The typical dose of Ondane is 8 mg of Ondane 30 minutes before starting radiotherapy or chemotherapy, followed by 8 mg dose 8 hours after the first dose. The usual dose for children is for 12-17 years of children, 8 mg is given 30 minutes before the start of the therapy, followed by 8 mg dose 4 and 8 hours after the first dose, followed by 8 mg thrice a day after completion of therapy.


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jaundice (yellowing of the skin or eyes); blurred vision or temporary vision loss (lasting from only a few minutes to several hours); high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting. Common ondansetron side effects may.


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Prophylaxis. Total body radiation therapy: 8 mg PO 1-2 hours before radiation therapy; administered each day. Single high-dose fraction therapy to abdomen: 8 mg PO 1-2 hr before radiation therapy; administer subsequent doses every 8 hr after first dose 1-2 days after completion of therapy. Daily fractions to abdomen: Administer 8 mg PO 1-2 hr.


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Infectious Diseases Society of America (IDSA) Recommendations: 30 mg/kg orally once a day. Maximum dose: 1 gram/day. Duration of therapy: 10 days. Comment: This drug should be avoided in patients with immediate hypersensitivity to penicillin. Use: Treatment of group A streptococcal pharyngitis in patients with penicillin allergies.


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Ondansetron may cause serious side effects. Call your doctor at once if you have: headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; blurred vision or temporary vision loss (lasting from only a few minutes to several hours); severe constipation, stomach pain, or bloating; a light-headed feeling, like you might.


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Pharmacodynamics. Ondansetron is a highly specific and selective serotonin 5-HT 3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors Label, 3,4.The serotonin 5-HT 3 receptors are located on the nerve terminals of the vagus in the periphery, and centrally in the chemoreceptor trigger zone of the area postrema Label, 3,4.


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Pharmacology : Ondansetron is a potent and selective 5-HT3 receptor antagonist. Administration of chemotherapy drugs and radiotherapy can cause the release of 5-HT3 into the intestine which will stimulate the gag reflex by activating vagal afferent fibers via 5-HT3 receptors. Ondansetron inhibits the initiation of this reflex.


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